PMEPA1
Summary: This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| prostate transmembrane protein, androgen induced 1 | MIM:606564 | Ensembl:ENSG00000124225 | HGNC:HGNC:14107 | PA162399822 | 20q13.31 |
GO terms in PMEPA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0010008 | endosome membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0031901 | early endosome membrane |
| CC | TAS | GO:0031901 | early endosome membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IDA | GO:0010991 | negative regulation of SMAD protein complex assembly |
| BP | IDA | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | NAS | GO:0030521 | androgen receptor signaling pathway |
| BP | IDA | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IMP | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0050699 | WW domain binding |
| MF | IPI | GO:0070412 | R-SMAD binding |
Gene expression in normal tissue: PMEPA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PMEPA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-2173788 | Downregulation of TGF-beta receptor signaling |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PMEPA1
CLASSFICATION
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