MIR181B2
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NamemicroRNA 181b-2 OMIM IDMIM:612745 Ensembl IDEnsembl:ENSG00000207737 HGNC IDHGNC:HGNC:31551 PHARMGKB IDPA164722524 Map Location9q33.3 | |||||
GO terms in MIR181B2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0035195 | gene silencing by miRNA |
| BP | IMP | GO:0035195 | gene silencing by miRNA |
| BP | IMP | GO:0035278 | miRNA mediated inhibition of translation |
| BP | ISS | GO:0110015 | positive regulation of elastin catabolic process |
| BP | ISS | GO:0120041 | positive regulation of macrophage proliferation |
Gene expression in normal tissue: MIR181B2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIR181B2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2029 | Cell Differentiation - Index |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD134 | Sorafenib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIR181B2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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