RAB34
Summary: This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:610917 Ensembl IDEnsembl:ENSG00000109113 HGNC IDHGNC:HGNC:16519 PHARMGKB IDPA34126 Map Location17q11.2 |
GO terms in RAB34
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0003924 | GTPase activity |
MF | IEA | GO:0003924 | GTPase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005525 | GTP binding |
MF | IPI | GO:0017160 | Ral GTPase binding |
MF | IPI | GO:0030742 | GTP-dependent protein binding |
Gene expression in normal tissue: RAB34
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAB34
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
reactome | R-HSA-392499 | Metabolism of proteins |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD134 | Sorafenib | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in RAB34
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |