Summary: This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016].

RAB34, member RAS oncogene familyMIM:610917Ensembl:ENSG00000109113HGNC:HGNC:16519PA3412617q11.2

GO terms in RAB34

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003924GTPase activity
MFIEAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding
MFIPIGO:0017160Ral GTPase binding
MFIPIGO:0030742GTP-dependent protein binding
BPIBAGO:0006886intracellular protein transport
BPIMPGO:0019882antigen processing and presentation
BPIEAGO:0030030cell projection organization
BPIDAGO:0032418lysosome localization
BPIBAGO:0032482Rab protein signal transduction
BPIDAGO:0043001Golgi to plasma membrane protein transport
BPISSGO:0045880positive regulation of smoothened signaling pathway
BPIDAGO:0072659protein localization to plasma membrane
BPIMPGO:0090382phagosome maturation
BPIMPGO:0090385phagosome-lysosome fusion
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005795Golgi stack
CCIBAGO:0012505endomembrane system
CCIEAGO:0030670phagocytic vesicle membrane
CCIDAGO:0031985Golgi cisterna
CCIDAGO:0032587ruffle membrane
CCIDAGO:0045335phagocytic vesicle
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: RAB34

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAB34

DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8873719RAB geranylgeranylation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAB34