RPL7
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:604166 Ensembl IDEnsembl:ENSG00000147604 HGNC IDHGNC:HGNC:10363 PHARMGKB IDPA34759 Map Location8q21.11 |
GO terms in RPL7
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0003677 | DNA binding |
MF | HDA | GO:0003723 | RNA binding |
MF | IDA | GO:0003729 | mRNA binding |
MF | IBA | GO:0003735 | structural constituent of ribosome |
MF | NAS | GO:0003735 | structural constituent of ribosome |
MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: RPL7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPL7
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa03010 | Ribosome - Homo sapiens (human) |
wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD134 | Sorafenib | 1 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in RPL7
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |