RPL7


Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:604166
PHARMGKB IDPA34759
Map Location8q21.11

GO terms in RPL7


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0003677 DNA binding
MF HDA GO:0003723 RNA binding
MF IDA GO:0003729 mRNA binding
MF IBA GO:0003735 structural constituent of ribosome
MF NAS GO:0003735 structural constituent of ribosome
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: RPL7

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

VEGF signaling pathway1

Pathways in RPL7


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Database
Pathway ID
Pathway Des.
kegg hsa03010 Ribosome - Homo sapiens (human)
wikipathways WP477 Cytoplasmic Ribosomal Proteins
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1430728 Metabolism
reactome R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
reactome R-HSA-156842 Eukaryotic Translation Elongation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD134 Sorafenib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPL7

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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