THBS1
Summary: The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thrombospondin 1 | MIM:188060 | Ensembl:ENSG00000137801 | HGNC:HGNC:11785 | PA36497 | 15q14 |
GO terms in THBS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0001786 | phosphatidylserine binding |
| MF | IDA | GO:0001968 | fibronectin binding |
| MF | IMP | GO:0005178 | integrin binding |
| MF | NAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0005515 | protein binding |
| MF | IDA | GO:0008201 | heparin binding |
| MF | IDA | GO:0017134 | fibroblast growth factor binding |
| MF | IDA | GO:0030169 | low-density lipoprotein particle binding |
| MF | NAS | GO:0042802 | identical protein binding |
| MF | IDA | GO:0043236 | laminin binding |
| MF | TAS | GO:0043394 | proteoglycan binding |
| MF | ISS | GO:0050431 | transforming growth factor beta binding |
| MF | TAS | GO:0050431 | transforming growth factor beta binding |
| MF | IDA | GO:0070051 | fibrinogen binding |
| MF | IDA | GO:0070052 | collagen V binding |
| BP | IMP | GO:0000187 | activation of MAPK activity |
| BP | NAS | GO:0001666 | response to hypoxia |
| BP | IDA | GO:0001937 | negative regulation of endothelial cell proliferation |
| BP | IMP | GO:0001937 | negative regulation of endothelial cell proliferation |
| BP | IDA | GO:0001953 | negative regulation of cell-matrix adhesion |
| BP | IMP | GO:0002040 | sprouting angiogenesis |
| BP | IEP | GO:0002544 | chronic inflammatory response |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | IDA | GO:0002581 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| BP | IDA | GO:0002605 | negative regulation of dendritic cell antigen processing and presentation |
| BP | IDA | GO:0006954 | inflammatory response |
| BP | IEP | GO:0006955 | immune response |
| BP | IEA | GO:0006986 | response to unfolded protein |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | NAS | GO:0007155 | cell adhesion |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IDA | GO:0009749 | response to glucose |
| BP | IDA | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IDA | GO:0010596 | negative regulation of endothelial cell migration |
| BP | IDA | GO:0010748 | negative regulation of plasma membrane long-chain fatty acid transport |
| BP | IDA | GO:0010751 | negative regulation of nitric oxide mediated signal transduction |
| BP | IDA | GO:0010754 | negative regulation of cGMP-mediated signaling |
| BP | IDA | GO:0010757 | negative regulation of plasminogen activation |
| BP | ISS | GO:0010759 | positive regulation of macrophage chemotaxis |
| BP | IDA | GO:0010763 | positive regulation of fibroblast migration |
| BP | IDA | GO:0016477 | cell migration |
| BP | IDA | GO:0016525 | negative regulation of angiogenesis |
| BP | IMP | GO:0016525 | negative regulation of angiogenesis |
| BP | IDA | GO:0018149 | peptide cross-linking |
| BP | IDA | GO:0030194 | positive regulation of blood coagulation |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0032026 | response to magnesium ion |
| BP | TAS | GO:0032570 | response to progesterone |
| BP | IDA | GO:0032695 | negative regulation of interleukin-12 production |
| BP | ISS | GO:0032914 | positive regulation of transforming growth factor beta1 production |
| BP | IEA | GO:0033574 | response to testosterone |
| BP | NAS | GO:0034605 | cellular response to heat |
| BP | ISS | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IDA | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| BP | IMP | GO:0042327 | positive regulation of phosphorylation |
| BP | IEP | GO:0042493 | response to drug |
| BP | IDA | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process |
| BP | IDA | GO:0043032 | positive regulation of macrophage activation |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IDA | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IDA | GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| BP | IDA | GO:0043652 | engulfment of apoptotic cell |
| BP | TAS | GO:0045652 | regulation of megakaryocyte differentiation |
| BP | IDA | GO:0045727 | positive regulation of translation |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | ISS | GO:0048266 | behavioral response to pain |
| BP | IDA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IDA | GO:0050921 | positive regulation of chemotaxis |
| BP | IDA | GO:0051592 | response to calcium ion |
| BP | TAS | GO:0051895 | negative regulation of focal adhesion assembly |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0051918 | negative regulation of fibrinolysis |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071363 | cellular response to growth factor stimulus |
| BP | IMP | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| BP | IDA | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IMP | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| BP | IGI | GO:1903671 | negative regulation of sprouting angiogenesis |
| BP | IDA | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| BP | IDA | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| BP | IDA | GO:2001027 | negative regulation of endothelial cell chemotaxis |
| BP | TAS | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| CC | HDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005577 | fibrinogen complex |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | ISS | GO:0016529 | sarcoplasmic reticulum |
| CC | IDA | GO:0030141 | secretory granule |
| CC | HDA | GO:0031012 | extracellular matrix |
| CC | IDA | GO:0031012 | extracellular matrix |
| CC | IDA | GO:0031091 | platelet alpha granule |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | ISS | GO:0062023 | collagen-containing extracellular matrix |
| CC | TAS | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: THBS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in THBS1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-3000170 | Syndecan interactions |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-3906995 | Diseases associated with O-glycosylation of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5083635 | Defective B3GALTL causes Peters-plus syndrome (PpS) |
| reactome | R-HSA-5173105 | O-linked glycosylation |
| reactome | R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP2806 | Human Complement System |
| wikipathways | WP2828 | Bladder Cancer |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP2911 | miRNA targets in ECM and membrane receptors |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4132 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP453 | Inflammatory Response Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | integrin3_pathway | Beta3 integrin cell surface interactions |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa05144 | Malaria - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in THBS1
CLASSFICATION
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