LCN2


Summary: This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:600181
PHARMGKB IDPA30309
Map Location9q34.11

GO terms in LCN2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0005506 iron ion binding
MF IEA GO:0036094 small molecule binding
CC HDA GO:0005576 extracellular region
CC ISS GO:0005576 extracellular region
CC TAS GO:0005576 extracellular region
CC HDA GO:0005615 extracellular space
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Gene expression in normal tissue: LCN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LCN2


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Database
Pathway ID
Pathway Des.
wikipathways WP4066 Interleukin-4 and 13 signaling
kegg hsa04657 IL-17 signaling pathway - Homo sapiens (human)
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-382551 Transport of small molecules
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD134 Sorafenib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LCN2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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