HMOX1
Summary: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameheme oxygenase 1 OMIM IDMIM:141250 Ensembl IDEnsembl:ENSG00000100292 HGNC IDHGNC:HGNC:5013 PHARMGKB IDPA29341 Map Location22q12.3 | |||||
GO terms in HMOX1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004392 | heme oxygenase (decyclizing) activity |
| MF | IDA | GO:0004392 | heme oxygenase (decyclizing) activity |
| MF | IMP | GO:0004392 | heme oxygenase (decyclizing) activity |
| MF | TAS | GO:0004392 | heme oxygenase (decyclizing) activity |
| MF | IEA | GO:0004630 | phospholipase D activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: HMOX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HMOX1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00860 | Porphyrin and chlorophyll metabolism - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04216 | Ferroptosis - Homo sapiens (human) |
| kegg | hsa04978 | Mineral absorption - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HMOX1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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