HMOX1


Summary: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
heme oxygenase 1MIM:141250Ensembl:ENSG00000100292HGNC:HGNC:5013PA2934122q12.3

GO terms in HMOX1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004392heme oxygenase (decyclizing) activity
MFIDAGO:0004392heme oxygenase (decyclizing) activity
MFIMPGO:0004392heme oxygenase (decyclizing) activity
MFTASGO:0004392heme oxygenase (decyclizing) activity
MFIEAGO:0004630phospholipase D activity
MFIPIGO:0005515protein binding
MFISSGO:0019899enzyme binding
MFIBAGO:0020037heme binding
MFIDAGO:0020037heme binding
MFIDAGO:0042803protein homodimerization activity
MFIEAGO:0046872metal ion binding
BPTASGO:0001525angiogenesis
BPTASGO:0001935endothelial cell proliferation
BPIMPGO:0002246wound healing involved in inflammatory response
BPTASGO:0002686negative regulation of leukocyte migration
BPIBAGO:0006788heme oxidation
BPIDAGO:0006788heme oxidation
BPIMPGO:0006879cellular iron ion homeostasis
BPTASGO:0006879cellular iron ion homeostasis
BPIBAGO:0006979response to oxidative stress
BPIMPGO:0006979response to oxidative stress
BPIEAGO:0007264small GTPase mediated signal transduction
BPICGO:0007588excretion
BPIEAGO:0008217regulation of blood pressure
BPISSGO:0008219cell death
BPIEAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0010656negative regulation of muscle cell apoptotic process
BPTASGO:0014806smooth muscle hyperplasia
BPIEAGO:0016239positive regulation of macroautophagy
BPIEAGO:0016242negative regulation of macroautophagy
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0031670cellular response to nutrient
BPIEAGO:0032764negative regulation of mast cell cytokine production
BPIMPGO:0034101erythrocyte homeostasis
BPTASGO:0034383low-density lipoprotein particle clearance
BPIEAGO:0034395regulation of transcription from RNA polymerase II promoter in response to iron
BPIMPGO:0034605cellular response to heat
BPIDAGO:0035094response to nicotine
BPTASGO:0035556intracellular signal transduction
BPIBAGO:0042167heme catabolic process
BPIDAGO:0042167heme catabolic process
BPTASGO:0042167heme catabolic process
BPISSGO:0042542response to hydrogen peroxide
BPIEAGO:0043065positive regulation of apoptotic process
BPHMPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043305negative regulation of mast cell degranulation
BPIEAGO:0043392negative regulation of DNA binding
BPIEAGO:0043433negative regulation of DNA-binding transcription factor activity
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPISSGO:0043619regulation of transcription from RNA polymerase II promoter in response to oxidative stress
BPIEAGO:0043627response to estrogen
BPTASGO:0045080positive regulation of chemokine biosynthetic process
BPTASGO:0045765regulation of angiogenesis
BPIDAGO:0045766positive regulation of angiogenesis
BPIDAGO:0048661positive regulation of smooth muscle cell proliferation
BPIDAGO:0048662negative regulation of smooth muscle cell proliferation
BPISSGO:0051090regulation of DNA-binding transcription factor activity
BPIDAGO:0051260protein homooligomerization
BPIBAGO:0055072iron ion homeostasis
BPIDAGO:0055072iron ion homeostasis
BPIMPGO:0055072iron ion homeostasis
BPIEAGO:0071243cellular response to arsenic-containing substance
BPIEAGO:0071276cellular response to cadmium ion
BPIEPGO:0071456cellular response to hypoxia
BPIEAGO:0072719cellular response to cisplatin
BPIGIGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
BPIEAGO:0097421liver regeneration
BPICGO:0097755positive regulation of blood vessel diameter
BPIMPGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPIGIGO:1903589positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
BPIEAGO:1904036negative regulation of epithelial cell apoptotic process
BPIEAGO:1904706negative regulation of vascular smooth muscle cell proliferation
CCTASGO:0005615extracellular space
CCISSGO:0005634nucleus
CCIEAGO:0005730nucleolus
CCIDAGO:0005783endoplasmic reticulum
CCISSGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0005829cytosol
CCIEAGO:0005901caveola
CCIBAGO:0016020membrane
CCTASGO:0016020membrane
CCIDAGO:0048471perinuclear region of cytoplasm

Gene expression in normal tissue: HMOX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HMOX1


DatabasePathway IDPathway Des.
kegghsa00860Porphyrin and chlorophyll metabolism - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04216Ferroptosis - Homo sapiens (human)
kegghsa04978Mineral absorption - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidfra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
pidhif1_tfpathwayHIF-1-alpha transcription factor network
humancycPWY-5874heme degradation
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP3Transcriptional activation by NRF2
wikipathwaysWP3287Overview of nanoparticle effects
wikipathwaysWP3612Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP408Oxidative Stress
smpdbSMP00024Porphyrin Metabolism
smpdbSMP00342Hereditary Coproporphyria (HCP)
smpdbSMP00344Acute Intermittent Porphyria
smpdbSMP00345Congenital Erythropoietic Porphyria (CEP) or Gunther Disease
smpdbSMP00346Porphyria Variegata (PV)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-168256Immune System
reactomeR-HSA-189445Metabolism of porphyrins
reactomeR-HSA-189483Heme degradation
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-917937Iron uptake and transport
biocartaarenrf2pathwayoxidative stress induced gene expression via nrf2
biocartail10pathwayil-10 anti-inflammatory signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD134Sorafenib1
iGMDRD30917AAG2
iGMDRD241Sunitinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HMOX1

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