SEARCH

HOME / SEARCH / ERLIN2

ERLIN2

Summary: This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].

Loading, please wait...

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameER lipid raft associated 2 OMIM IDMIM:611605 Ensembl IDEnsembl:ENSG00000147475 HGNC IDHGNC:HGNC:1356 PHARMGKB IDPA25961 Map Location8p11.23

Gene Categories:

TYROSINE KINASE KINASE

GO terms in ERLIN2

Loading, please wait...

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005783	endoplasmic reticulum
CC	IBA	GO:0005789	endoplasmic reticulum membrane
CC	IDA	GO:0005789	endoplasmic reticulum membrane
CC	TAS	GO:0005789	endoplasmic reticulum membrane
CC	IDA	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane

Showing 1 to 6 of 22 rows rows per page

Gene expression in normal tissue: ERLIN2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ERLIN2

Loading, please wait...

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1226099	Signaling by FGFR in disease
reactome	R-HSA-1643685	Disease
reactome	R-HSA-1839124	FGFR1 mutant receptor activation
reactome	R-HSA-382551	Transport of small molecules
reactome	R-HSA-382556	ABC-family proteins mediated transport
reactome	R-HSA-5619084	ABC transporter disorders

Showing 1 to 6 of 11 rows rows per page

Gene-Drug: Aster Plot

Loading, please wait...

Drug ID	Drug Name	Model Num.
iGMDRD268	Cerulenin	2
iGMDRD322	FK 866	2
iGMDRD300	Tozasertib	1
iGMDRD60	Quinoclamine	3

Showing 1 to 4 of 29 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ERLIN2

Loading, please wait...

	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.