S100A6
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:114110 Ensembl IDEnsembl:ENSG00000197956 HGNC IDHGNC:HGNC:10496 PHARMGKB IDPA34908 Map Location1q21.3 | |||||
Gene Categories:
TRANSPORTERGO terms in S100A6
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | NAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005523 | tropomyosin binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0015075 | ion transmembrane transporter activity |
Gene expression in normal tissue: S100A6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in S100A6
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in S100A6
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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