S100A6
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| S100 calcium binding protein A6 | MIM:114110 | Ensembl:ENSG00000197956 | HGNC:HGNC:10496 | PA34908 | 1q21.3 |
Gene Categories:
TRANSPORTERGO terms in S100A6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | NAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005523 | tropomyosin binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0015075 | ion transmembrane transporter activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0044548 | S100 protein binding |
| MF | IDA | GO:0048306 | calcium-dependent protein binding |
| BP | TAS | GO:0007165 | signal transduction |
| BP | NAS | GO:0007409 | axonogenesis |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | NAS | GO:0048146 | positive regulation of fibroblast proliferation |
| CC | IDA | GO:0001726 | ruffle |
| CC | HDA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | NAS | GO:0005635 | nuclear envelope |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: S100A6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in S100A6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2363 | Gastric Cancer Network 2 |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in S100A6
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