MYO6
Summary: This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namemyosin VI OMIM IDMIM:600970 Ensembl IDEnsembl:ENSG00000196586 HGNC IDHGNC:HGNC:7605 PHARMGKB IDPA31410 Map Location6q14.1 | |||||
Gene Categories:
DRUG RESISTANCEGO terms in MYO6
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0006886 | intracellular protein transport |
| BP | IMP | GO:0006897 | endocytosis |
| BP | ISS | GO:0006897 | endocytosis |
| BP | IEA | GO:0007018 | microtubule-based movement |
| BP | IEA | GO:0007605 | sensory perception of sound |
| BP | ISS | GO:0030048 | actin filament-based movement |
Gene expression in normal tissue: MYO6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYO6
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD134 | Sorafenib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYO6
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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