PTDSS1


Summary: The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014].

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GO terms in PTDSS1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC ISS GO:0005789 endoplasmic reticulum membrane
CC TAS GO:0005789 endoplasmic reticulum membrane
CC HDA GO:0016020 membrane
CC ISS GO:0016020 membrane
CC IEA GO:0016021 integral component of membrane
BP IEA GO:0006659 phosphatidylserine biosynthetic process
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Gene expression in normal tissue: PTDSS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTDSS1


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Database
Pathway ID
Pathway Des.
smpdb SMP00025 Phospholipid Biosynthesis
wikipathways WP3933 Kennedy pathway from Sphingolipids
humancyc PWY-7501 phosphatidylserine biosynthesis I
kegg hsa00564 Glycerophospholipid metabolism - Homo sapiens (human)
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1483101 Synthesis of PS
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD134 Sorafenib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTDSS1

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Cancer
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No matching records found

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