FRAT2
Summary: The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FRAT2, WNT signaling pathway regulator | MIM:605006 | Ensembl:ENSG00000181274 | HGNC:HGNC:16048 | PA28362 | 10q24.1 |
GO terms in FRAT2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| CC | ND | GO:0005575 | cellular_component |
| CC | TAS | GO:0005829 | cytosol |
| BP | NAS | GO:0007275 | multicellular organism development |
| BP | NAS | GO:0008283 | cell proliferation |
| BP | TAS | GO:1904886 | beta-catenin destruction complex disassembly |
Gene expression in normal tissue: FRAT2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FRAT2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-196299 | Beta-catenin phosphorylation cascade |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FRAT2
CLASSFICATION
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