GPRC5A
Summary: This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604138 Ensembl IDEnsembl:ENSG00000013588 HGNC IDHGNC:HGNC:9836 PHARMGKB IDPA34194 Map Location12p13.1 | |||||
GO terms in GPRC5A
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007165 | signal transduction |
| BP | ISS | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
Gene expression in normal tissue: GPRC5A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPRC5A
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP501 | GPCRs, Class C Metabotropic glutamate, pheromone |
| netpath | Pathway_EGFR1 | EGFR1 |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD134 | Sorafenib | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPRC5A
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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