NTN4
Summary: This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| netrin 4 | MIM:610401 | Ensembl:ENSG00000074527 | HGNC:HGNC:13658 | PA31815 | 12q22 |
Gene Categories:
DRUGGABLE GENOMEGO terms in NTN4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0043237 | laminin-1 binding |
| CC | IEA | GO:0005604 | basement membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0016322 | neuron remodeling |
| BP | IEA | GO:0060668 | regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling |
Gene expression in normal tissue: NTN4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTN4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-422475 | Axon guidance |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTN4
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