CUX1
Summary: The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:116896 Ensembl IDEnsembl:ENSG00000257923 HGNC IDHGNC:HGNC:2557 PHARMGKB IDPA162382924 Map Location7q22.1 | |||||
GO terms in CUX1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISS | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030674 | protein binding, bridging |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
Gene expression in normal tissue: CUX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CUX1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD134 | Sorafenib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CUX1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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