PPY
Summary: This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pancreatic polypeptide | MIM:167780 | Ensembl:ENSG00000108849 | HGNC:HGNC:9327 | PA33690 | 17q21.31 |
GO terms in PPY
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007218 | neuropeptide signaling pathway |
| BP | IBA | GO:0007267 | cell-cell signaling |
| BP | IBA | GO:0007631 | feeding behavior |
| BP | TAS | GO:0009306 | protein secretion |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005737 | cytoplasm |
| MF | IBA | GO:0001664 | G-protein coupled receptor binding |
| MF | IPI | GO:0001664 | G-protein coupled receptor binding |
| MF | IBA | GO:0005179 | hormone activity |
| MF | TAS | GO:0005179 | hormone activity |
| MF | IBA | GO:0005184 | neuropeptide hormone activity |
Gene expression in normal tissue: PPY
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPY
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPY
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