TMEFF2
Summary: This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transmembrane protein with EGF like and two follistatin like domains 2 | MIM:605734 | Ensembl:ENSG00000144339 | HGNC:HGNC:11867 | PA36568 | 2q32.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TMEFF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0030336 | negative regulation of cell migration |
| BP | IDA | GO:0044319 | wound healing, spreading of cells |
| BP | IMP | GO:0045720 | negative regulation of integrin biosynthetic process |
| BP | IDA | GO:0051497 | negative regulation of stress fiber assembly |
| CC | IEA | GO:0005576 | extracellular region |
| CC | NAS | GO:0016021 | integral component of membrane |
| MF | ND | GO:0003674 | molecular_function |
Gene expression in normal tissue: TMEFF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TMEFF2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TMEFF2
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