PPP1R13L


Summary: IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein phosphatase 1 regulatory subunit 13 likeMIM:607463Ensembl:ENSG00000104881HGNC:HGNC:18838PA3419519q13.32

GO terms in PPP1R13L


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCIDAGO:0030054cell junction
CCIDAGO:0045171intercellular bridge
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0003215cardiac right ventricle morphogenesis
BPIEAGO:0003229ventricular cardiac muscle tissue development
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006915apoptotic process
BPIEAGO:0009791post-embryonic development
BPIEAGO:0031076embryonic camera-type eye development
BPIEAGO:0035264multicellular organism growth
BPIEAGO:0042633hair cycle
BPIEAGO:0045597positive regulation of cell differentiation
BPIEAGO:0048871multicellular organismal homeostasis
BPIEAGO:0060048cardiac muscle contraction
BPTASGO:1901796regulation of signal transduction by p53 class mediator
MFTASGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008134transcription factor binding
MFIPIGO:0042802identical protein binding
MFHDAGO:0045296cadherin binding

Gene expression in normal tissue: PPP1R13L

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPP1R13L


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-6804759Regulation of TP53 Activity through Association with Co-factors
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
netpathPathway_TNFalphaTNFalpha
pidp53regulationpathwayp53 pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD133Lapatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP1R13L

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