PPP1R13L
Summary: IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:607463 Ensembl IDEnsembl:ENSG00000104881 HGNC IDHGNC:HGNC:18838 PHARMGKB IDPA34195 Map Location19q13.32 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in PPP1R13L
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | TAS | GO:0005634 | nucleus |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005829 | cytosol |
CC | IDA | GO:0030054 | cell junction |
CC | IDA | GO:0045171 | intercellular bridge |
BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: PPP1R13L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP1R13L
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-212436 | Generic Transcription Pathway |
reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
reactome | R-HSA-5633007 | Regulation of TP53 Activity |
reactome | R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors |
reactome | R-HSA-73857 | RNA Polymerase II Transcription |
reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD133 | Lapatinib | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PPP1R13L
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |