SEPT3
Summary: This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2018].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| septin 3 | MIM:608314 | Ensembl:ENSG00000100167 | HGNC:HGNC:10750 | PA24355 | 22q13.2 |
GO terms in SEPT3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005940 | septin ring |
| CC | IBA | GO:0015630 | microtubule cytoskeleton |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0031105 | septin complex |
| CC | IBA | GO:0032153 | cell division site |
| CC | IBA | GO:0032160 | septin filament array |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IEA | GO:0045202 | synapse |
| CC | IBA | GO:0099569 | presynaptic cytoskeleton |
| BP | IBA | GO:0000281 | mitotic cytokinesis |
| BP | IBA | GO:0000921 | septin ring assembly |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0034613 | cellular protein localization |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:0060271 | cilium assembly |
| MF | ND | GO:0003674 | molecular_function |
| MF | IBA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IBA | GO:0032947 | protein-containing complex scaffold activity |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: SEPT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEPT3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD133 | Lapatinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEPT3
CLASSFICATION
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