TFAP2C
Summary: The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transcription factor AP-2 gamma | MIM:601602 | Ensembl:ENSG00000087510 | HGNC:HGNC:11744 | PA36461 | 20q13.31 |
GO terms in TFAP2C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IEP | GO:0008584 | male gonad development |
| BP | IMP | GO:0040029 | regulation of gene expression, epigenetic |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0048856 | anatomical structure development |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0046983 | protein dimerization activity |
Gene expression in normal tissue: TFAP2C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TFAP2C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3232118 | SUMOylation of transcription factors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| reactome | R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| reactome | R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors |
| reactome | R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors |
| reactome | R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors |
| reactome | R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors |
| reactome | R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptors |
| reactome | R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors |
| wikipathways | WP2858 | Ectoderm Differentiation |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TFAP2C
CLASSFICATION
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