ANKRD2


Summary: This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ankyrin repeat domain 2MIM:610734Ensembl:ENSG00000165887HGNC:HGNC:495PA2480410q24.2

GO terms in ANKRD2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003682chromatin binding
MFIBAGO:0003712transcription coregulator activity
MFNASGO:0008307structural constituent of muscle
MFIBAGO:0031432titin binding
MFIPIGO:0043422protein kinase B binding
MFIBAGO:0061629RNA polymerase II sequence-specific DNA-binding transcription factor binding
MFIDAGO:0061629RNA polymerase II sequence-specific DNA-binding transcription factor binding
CCISSGO:0000791euchromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCIEAGO:0016605PML body
CCIBAGO:0031674I band
CCISSGO:0031674I band
CCIDAGO:0043231intracellular membrane-bounded organelle
BPIGIGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001817regulation of cytokine production
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPNASGO:0006936muscle contraction
BPNASGO:0007517muscle organ development
BPIEAGO:0010832negative regulation of myotube differentiation
BPIBAGO:0035914skeletal muscle cell differentiation
BPIDAGO:0043619regulation of transcription from RNA polymerase II promoter in response to oxidative stress
BPIBAGO:0045445myoblast differentiation
BPIMPGO:0045662negative regulation of myoblast differentiation
BPIEAGO:1902253regulation of intrinsic apoptotic signaling pathway by p53 class mediator
BPIEAGO:2000291regulation of myoblast proliferation

Gene expression in normal tissue: ANKRD2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ANKRD2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD133Lapatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ANKRD2

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