ANKRD2
Summary: This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ankyrin repeat domain 2 | MIM:610734 | Ensembl:ENSG00000165887 | HGNC:HGNC:495 | PA24804 | 10q24.2 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in ANKRD2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003712 | transcription coregulator activity |
| MF | NAS | GO:0008307 | structural constituent of muscle |
| MF | IBA | GO:0031432 | titin binding |
| MF | IPI | GO:0043422 | protein kinase B binding |
| MF | IBA | GO:0061629 | RNA polymerase II sequence-specific DNA-binding transcription factor binding |
| MF | IDA | GO:0061629 | RNA polymerase II sequence-specific DNA-binding transcription factor binding |
| CC | ISS | GO:0000791 | euchromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0016605 | PML body |
| CC | IBA | GO:0031674 | I band |
| CC | ISS | GO:0031674 | I band |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IGI | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001817 | regulation of cytokine production |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | NAS | GO:0006936 | muscle contraction |
| BP | NAS | GO:0007517 | muscle organ development |
| BP | IEA | GO:0010832 | negative regulation of myotube differentiation |
| BP | IBA | GO:0035914 | skeletal muscle cell differentiation |
| BP | IDA | GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress |
| BP | IBA | GO:0045445 | myoblast differentiation |
| BP | IMP | GO:0045662 | negative regulation of myoblast differentiation |
| BP | IEA | GO:1902253 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| BP | IEA | GO:2000291 | regulation of myoblast proliferation |
Gene expression in normal tissue: ANKRD2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANKRD2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANKRD2
CLASSFICATION
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