EIF4A2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 4A2 | MIM:601102 | Ensembl:ENSG00000156976 | HGNC:HGNC:3284 | PA27712 | 3q27.3 |
GO terms in EIF4A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0003743 | translation initiation factor activity |
| MF | TAS | GO:0004386 | helicase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016887 | ATPase activity |
| BP | TAS | GO:0006413 | translational initiation |
| BP | TAS | GO:0006446 | regulation of translational initiation |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:1900260 | negative regulation of RNA-directed 5'-3' RNA polymerase activity |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0016281 | eukaryotic translation initiation factor 4F complex |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: EIF4A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF4A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-429914 | Deadenylation-dependent mRNA decay |
| reactome | R-HSA-429947 | Deadenylation of mRNA |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72649 | Translation initiation complex formation |
| reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-913531 | Interferon Signaling |
| biocarta | eifpathway | eukaryotic protein translation |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| wikipathways | WP107 | Translation Factors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD882 | CIL41 | 3 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD1002 | rTRAIL | 1 |
| iGMDRD605 | AZD6482 | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD599 | Salermide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF4A2
CLASSFICATION
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