NRG1


Summary: The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
neuregulin 1MIM:142445Ensembl:ENSG00000157168HGNC:HGNC:7997PA317768p12

GO terms in NRG1


Term TypeEvidence TypeGO Term IDGO Des.
CCNASGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIEAGO:0005887integral component of plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCNASGO:0016020membrane
CCIEAGO:0030425dendrite
CCIEAGO:0030673axolemma
CCIEAGO:0031594neuromuscular junction
CCIEAGO:0044297cell body
BPTASGO:0000165MAPK cascade
BPIMPGO:0000187activation of MAPK activity
BPIEAGO:0000902cell morphogenesis
BPIEAGO:0001964startle response
BPIEAGO:0003161cardiac conduction system development
BPIDAGO:0003222ventricular trabecula myocardium morphogenesis
BPTASGO:0007154cell communication
BPIBAGO:0007171activation of transmembrane receptor protein tyrosine kinase activity
BPIEAGO:0007171activation of transmembrane receptor protein tyrosine kinase activity
BPIBAGO:0007399nervous system development
BPTASGO:0007399nervous system development
BPIEAGO:0007416synapse assembly
BPIEAGO:0007422peripheral nervous system development
BPIEAGO:0007626locomotory behavior
BPIMPGO:0008284positive regulation of cell proliferation
BPIEAGO:0008366axon ensheathment
BPIEAGO:0009790embryo development
BPIEAGO:0010469regulation of signaling receptor activity
BPTASGO:0014032neural crest cell development
BPIEAGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0021781glial cell fate commitment
BPIEAGO:0021842chemorepulsion involved in interneuron migration from the subpallium to the cortex
BPIBAGO:0030154cell differentiation
BPTASGO:0030879mammary gland development
BPIEAGO:0031643positive regulation of myelination
BPIMPGO:0032148activation of protein kinase B activity
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0038127ERBB signaling pathway
BPIMPGO:0038127ERBB signaling pathway
BPTASGO:0038128ERBB2 signaling pathway
BPIDAGO:0038129ERBB3 signaling pathway
BPTASGO:0042060wound healing
BPIEAGO:0042177negative regulation of protein catabolic process
BPTASGO:0043496regulation of protein homodimerization activity
BPIDAGO:0043497regulation of protein heterodimerization activity
BPIEAGO:0045213neurotransmitter receptor metabolic process
BPIEAGO:0045773positive regulation of axon extension
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046579positive regulation of Ras protein signal transduction
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIBAGO:0048513animal organ development
BPIEAGO:0048663neuron fate commitment
BPIEAGO:0048709oligodendrocyte differentiation
BPIEAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIDAGO:0051048negative regulation of secretion
BPISSGO:0051155positive regulation of striated muscle cell differentiation
BPTASGO:0051897positive regulation of protein kinase B signaling
BPISSGO:0055007cardiac muscle cell differentiation
BPIDAGO:0060379cardiac muscle cell myoblast differentiation
BPIDAGO:0060956endocardial cell differentiation
BPIEAGO:0060999positive regulation of dendritic spine development
BPIEAGO:0070886positive regulation of calcineurin-NFAT signaling cascade
BPIEAGO:2000010positive regulation of protein localization to cell surface
BPTASGO:2000145regulation of cell motility
BPIEAGO:2000727positive regulation of cardiac muscle cell differentiation
BPIEAGO:2001223negative regulation of neuron migration
MFIDAGO:0003712transcription coregulator activity
MFTASGO:0004713protein tyrosine kinase activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIBAGO:0005102signaling receptor binding
MFTASGO:0005125cytokine activity
MFIEAGO:0005176ErbB-2 class receptor binding
MFIDAGO:0005178integrin binding
MFNASGO:0008083growth factor activity
MFIBAGO:0030296protein tyrosine kinase activator activity
MFNASGO:0030297transmembrane receptor protein tyrosine kinase activator activity
MFNASGO:0030971receptor tyrosine kinase binding
MFIDAGO:0043125ErbB-3 class receptor binding
MFIEAGO:0045499chemorepellent activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Gene expression in normal tissue: NRG1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NRG1


DatabasePathway IDPathway Des.
biocartaagrpathwayagrin in postsynaptic differentiation
biocartaerbb3pathwayneuroregulin receptor degredation protein-1 controls erbb3 receptor recycling
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1250342PI3K events in ERBB4 signaling
reactomeR-HSA-1250347SHC1 events in ERBB4 signaling
reactomeR-HSA-1251985Nuclear signaling by ERBB4
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1306955GRB7 events in ERBB2 signaling
reactomeR-HSA-1358803Downregulation of ERBB2:ERBB3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1963640GRB2 events in ERBB2 signaling
reactomeR-HSA-1963642PI3K events in ERBB2 signaling
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6785631ERBB2 Regulates Cell Motility
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-8847993ERBB2 Activates PTK6 Signaling
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8863795Downregulation of ERBB2 signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP673ErbB Signaling Pathway
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
piderbb4_pathwayErbB4 signaling events
piderbb_network_pathwayErbB receptor signaling network
pidglypican_1pathwayGlypican 1 network
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD817Anti-ERBB3 Agents1
iGMDRD829AV-2031
iGMDRD133Lapatinib1
iGMDRD288Carboplatin1
iGMDRD160Cis-Platin1
iGMDRD68Paclitaxel1
iGMDRD79Gemcitabine1
iGMDRD972Patritumab1
iGMDRD792Cetuximab1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NRG1

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