CLCA2
Summary: This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| chloride channel accessory 2 | MIM:604003 | Ensembl:ENSG00000137975 | HGNC:HGNC:2016 | PA26543 | 1p22.3 |
GO terms in CLCA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | IBA | GO:0005229 | intracellular calcium activated chloride channel activity |
| MF | TAS | GO:0005254 | chloride channel activity |
| MF | IEA | GO:0015276 | ligand-gated ion channel activity |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009925 | basal plasma membrane |
| CC | IDA | GO:0030054 | cell junction |
| CC | IDA | GO:0031965 | nuclear membrane |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:1902476 | chloride transmembrane transport |
Gene expression in normal tissue: CLCA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLCA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p73pathway | p73 transcription factor network |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLCA2
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