Summary: This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016].

chloride channel accessory 2MIM:604003Ensembl:ENSG00000137975HGNC:HGNC:2016PA265431p22.3

GO terms in CLCA2

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004222metalloendopeptidase activity
MFIBAGO:0005229intracellular calcium activated chloride channel activity
MFTASGO:0005254chloride channel activity
MFIEAGO:0015276ligand-gated ion channel activity
MFIEAGO:0046872metal ion binding
CCIEAGO:0005576extracellular region
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0009925basal plasma membrane
CCIDAGO:0030054cell junction
CCIDAGO:0031965nuclear membrane
BPIEAGO:0007155cell adhesion
BPTASGO:0034220ion transmembrane transport
BPIEAGO:1902476chloride transmembrane transport

Gene expression in normal tissue: CLCA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLCA2

DatabasePathway IDPathway Des.
pidp73pathwayp73 transcription factor network
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLCA2