IL13RA2
Summary: The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 13 receptor subunit alpha 2 | MIM:300130 | Ensembl:ENSG00000123496 | HGNC:HGNC:5975 | PA29788 | Xq23 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IL13RA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002638 | negative regulation of immunoglobulin production |
| BP | IEA | GO:0016064 | immunoglobulin mediated immune response |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0043305 | negative regulation of mast cell degranulation |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005615 | extracellular space |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043235 | receptor complex |
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | TAS | GO:0004896 | cytokine receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0019955 | cytokine binding |
Gene expression in normal tissue: IL13RA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL13RA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| pid | il4_2pathway | IL4-mediated signaling events |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL13RA2
CLASSFICATION
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