Summary: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011].

nectin cell adhesion molecule 4MIM:609607Ensembl:ENSG00000143217HGNC:HGNC:19688PA1349916241q23.3

Gene Categories:


GO terms in NECTIN4

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFIBAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0042803protein homodimerization activity
MFIBAGO:0050839cell adhesion molecule binding
BPIBAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIBAGO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
BPIBAGO:0008037cell recognition
BPTASGO:0034332adherens junction organization
BPIEAGO:0046718viral entry into host cell
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005913cell-cell adherens junction
CCIDAGO:0005913cell-cell adherens junction
CCIBAGO:0043296apical junction complex
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: NECTIN4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NECTIN4

DatabasePathway IDPathway Des.
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-418990Adherens junctions interactions
reactomeR-HSA-420597Nectin/Necl trans heterodimerization
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-446728Cell junction organization
kegghsa04520Adherens junction - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NECTIN4