NECTIN4


Summary: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
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Gene Categories:

DRUGGABLE GENOME

GO terms in NECTIN4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0001618 virus receptor activity
MF IBA GO:0005102 signaling receptor binding
MF IPI GO:0005515 protein binding
MF IPI GO:0042802 identical protein binding
MF IBA GO:0042803 protein homodimerization activity
MF IBA GO:0050839 cell adhesion molecule binding
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Gene expression in normal tissue: NECTIN4

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Breast cancer1

Pathways in NECTIN4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1500931 Cell-Cell communication
reactome R-HSA-418990 Adherens junctions interactions
reactome R-HSA-420597 Nectin/Necl trans heterodimerization
reactome R-HSA-421270 Cell-cell junction organization
reactome R-HSA-446728 Cell junction organization
kegg hsa04520 Adherens junction - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD133 Lapatinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NECTIN4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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