GAST
Summary: Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| gastrin | MIM:137250 | Ensembl:ENSG00000184502 | HGNC:HGNC:4164 | PA28577 | 17q21.2 |
GO terms in GAST
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005179 | hormone activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IBA | GO:0032094 | response to food |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
Gene expression in normal tissue: GAST
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAST
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| netpath | Pathway_Gastrin | Gastrin |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| smpdb | SMP00225 | Esomeprazole Action Pathway |
| smpdb | SMP00226 | Omeprazole Action Pathway |
| smpdb | SMP00227 | Lansoprazole Action Pathway |
| smpdb | SMP00228 | Pantoprazole Action Pathway |
| smpdb | SMP00229 | Rabeprazole Action Pathway |
| smpdb | SMP00230 | Ranitidine Action Pathway |
| smpdb | SMP00231 | Famotidine Action Pathway |
| smpdb | SMP00232 | Cimetidine Action Pathway |
| smpdb | SMP00233 | Nizatidine Action Pathway |
| smpdb | SMP00246 | Pirenzepine Action Pathway |
| smpdb | SMP00589 | Gastric Acid Production |
| smpdb | SMP00734 | Roxatidine acetate Action Pathway |
| smpdb | SMP00735 | Metiamide Action Pathway |
| smpdb | SMP00736 | Betazole Action Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GAST
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.