ADAMTSL1


Summary: This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ADAMTS like 1MIM:609198Ensembl:ENSG00000178031HGNC:HGNC:14632PA245549p22.2-p22.1

GO terms in ADAMTSL1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0008233peptidase activity
BPIEAGO:0006508proteolysis
CCIEAGO:0005576extracellular region
CCTASGO:0005788endoplasmic reticulum lumen

Gene expression in normal tissue: ADAMTSL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADAMTSL1


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-3906995Diseases associated with O-glycosylation of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)
reactomeR-HSA-5173105O-linked glycosylation
reactomeR-HSA-5173214O-glycosylation of TSR domain-containing proteins
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD133Lapatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAMTSL1

​​​​