RHOBTB2


Summary: The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Rho related BTB domain containing 2MIM:607352Ensembl:ENSG00000008853HGNC:HGNC:18756PA386788p21.3

GO terms in RHOBTB2


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0005856cytoskeleton
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
BPIBAGO:0000902cell morphogenesis
BPIBAGO:0006897endocytosis
BPIBAGO:0006935chemotaxis
BPIBAGO:0007015actin filament organization
BPIEAGO:0007264small GTPase mediated signal transduction
BPIBAGO:0007266Rho protein signal transduction
BPIBAGO:0016477cell migration
BPIBAGO:0030036actin cytoskeleton organization
BPIBAGO:0030838positive regulation of actin filament polymerization
BPIBAGO:0031532actin cytoskeleton reorganization
BPIBAGO:0043652engulfment of apoptotic cell
BPTASGO:0051056regulation of small GTPase mediated signal transduction
MFIBAGO:0003924GTPase activity
MFIEAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIBAGO:0005525GTP binding
MFIEAGO:0005525GTP binding
MFIBAGO:0019901protein kinase binding

Gene expression in normal tissue: RHOBTB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RHOBTB2


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD133Lapatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RHOBTB2

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