AMZ2
Summary: The protein encoded by this gene is a zinc metalloprotease that displays some activity against angiotensin-3. The encoded protein is inhibited by the aminopeptidase inhibitor amastatin, as well as by the general inhibitors o-phenanthroline and batimastat. Defects in this gene may be associated with lung tumorigenesis. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| archaelysin family metallopeptidase 2 | MIM:615169 | Ensembl:ENSG00000196704 | HGNC:HGNC:28041 | PA162376414 | 17q24.2 |
GO terms in AMZ2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0008233 | peptidase activity |
| MF | IEA | GO:0008237 | metallopeptidase activity |
| MF | IEA | GO:0008270 | zinc ion binding |
| BP | IMP | GO:0006508 | proteolysis |
| CC | ND | GO:0005575 | cellular_component |
Gene expression in normal tissue: AMZ2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AMZ2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD351 | GW843682X | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AMZ2
CLASSFICATION
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