AMZ2


Summary: The protein encoded by this gene is a zinc metalloprotease that displays some activity against angiotensin-3. The encoded protein is inhibited by the aminopeptidase inhibitor amastatin, as well as by the general inhibitors o-phenanthroline and batimastat. Defects in this gene may be associated with lung tumorigenesis. [provided by RefSeq, Oct 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
archaelysin family metallopeptidase 2MIM:615169Ensembl:ENSG00000196704HGNC:HGNC:28041PA16237641417q24.2

GO terms in AMZ2


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0008233peptidase activity
MFIEAGO:0008237metallopeptidase activity
MFIEAGO:0008270zinc ion binding
BPIMPGO:0006508proteolysis
CCNDGO:0005575cellular_component

Gene expression in normal tissue: AMZ2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AMZ2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD705Nakiterpiosin4
iGMDRD77Itraconazole2
iGMDRD255SB2250021
iGMDRD60Quinoclamine1
iGMDRD886Compound 1541A2
iGMDRD887Compound 23 citrate3
iGMDRD446LY 21832402
iGMDRD133Lapatinib1
iGMDRD871BRD63681
iGMDRD286Nsc 6328395
iGMDRD237ABT-7513
iGMDRD61Kinetin riboside3
iGMDRD577BIX012942
iGMDRD351GW843682X5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AMZ2

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