IL36RN
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 36 receptor antagonist | MIM:605507 | Ensembl:ENSG00000136695 | HGNC:HGNC:15561 | PA38388 | 2q14.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IL36RN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005149 | interleukin-1 receptor binding |
| MF | IEA | GO:0005152 | interleukin-1 receptor antagonist activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| BP | IBA | GO:0001960 | negative regulation of cytokine-mediated signaling pathway |
| BP | IMP | GO:0001960 | negative regulation of cytokine-mediated signaling pathway |
| BP | IBA | GO:0002437 | inflammatory response to antigenic stimulus |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IBA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0019732 | antifungal humoral response |
| BP | IMP | GO:0019732 | antifungal humoral response |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | IBA | GO:0032700 | negative regulation of interleukin-17 production |
| BP | IMP | GO:0032700 | negative regulation of interleukin-17 production |
| BP | IBA | GO:0032715 | negative regulation of interleukin-6 production |
| BP | IEA | GO:0032715 | negative regulation of interleukin-6 production |
| BP | IBA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IBA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IBA | GO:0046330 | positive regulation of JNK cascade |
| BP | IBA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IBA | GO:1902714 | negative regulation of interferon-gamma secretion |
| BP | IMP | GO:1902714 | negative regulation of interferon-gamma secretion |
Gene expression in normal tissue: IL36RN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL36RN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-9014826 | Interleukin-36 pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL36RN
CLASSFICATION
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