IL36RN


Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interleukin 36 receptor antagonistMIM:605507Ensembl:ENSG00000136695HGNC:HGNC:15561PA383882q14.1

Gene Categories:

DRUGGABLE GENOME

GO terms in IL36RN


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005125cytokine activity
MFIBAGO:0005149interleukin-1 receptor binding
MFIEAGO:0005152interleukin-1 receptor antagonist activity
MFIPIGO:0005515protein binding
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
BPIBAGO:0001960negative regulation of cytokine-mediated signaling pathway
BPIMPGO:0001960negative regulation of cytokine-mediated signaling pathway
BPIBAGO:0002437inflammatory response to antigenic stimulus
BPIEAGO:0006954inflammatory response
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0019732antifungal humoral response
BPIMPGO:0019732antifungal humoral response
BPIBAGO:0030593neutrophil chemotaxis
BPIBAGO:0032700negative regulation of interleukin-17 production
BPIMPGO:0032700negative regulation of interleukin-17 production
BPIBAGO:0032715negative regulation of interleukin-6 production
BPIEAGO:0032715negative regulation of interleukin-6 production
BPIBAGO:0032755positive regulation of interleukin-6 production
BPIBAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0045087innate immune response
BPIBAGO:0046330positive regulation of JNK cascade
BPIBAGO:0071222cellular response to lipopolysaccharide
BPIBAGO:1902714negative regulation of interferon-gamma secretion
BPIMPGO:1902714negative regulation of interferon-gamma secretion

Gene expression in normal tissue: IL36RN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL36RN


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-9014826Interleukin-36 pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD133Lapatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL36RN

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