KRT17


Summary: This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
keratin 17MIM:148069Ensembl:ENSG00000128422HGNC:HGNC:6427PA3021417q21.2

GO terms in KRT17


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005200structural constituent of cytoskeleton
MFIPIGO:0005515protein binding
MFIDAGO:0032395MHC class II receptor activity
MFIPIGO:0042289MHC class II protein binding
BPIMPGO:0007165signal transduction
BPTASGO:0008544epidermis development
BPIEAGO:0030307positive regulation of cell growth
BPISSGO:0031069hair follicle morphogenesis
BPTASGO:0031424keratinization
BPIEAGO:0045109intermediate filament organization
BPIEAGO:0045727positive regulation of translation
BPIEAGO:0051798positive regulation of hair follicle development
BPTASGO:0070268cornification
CCTASGO:0005829cytosol
CCIEAGO:0005882intermediate filament
CCIDAGO:0045111intermediate filament cytoskeleton
CCHDAGO:0070062extracellular exosome
CCIEAGO:0071944cell periphery

Gene expression in normal tissue: KRT17

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KRT17


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-6805567Keratinization
reactomeR-HSA-6809371Formation of the cornified envelope
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
netpathPathway_EGFR1EGFR1
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD133Lapatinib1
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KRT17

​​​​