EXTL1


Summary: This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in EXTL1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
CC TAS GO:0005789 endoplasmic reticulum membrane
CC IEA GO:0016021 integral component of membrane
BP TAS GO:0001501 skeletal system development
BP IEA GO:0006486 protein glycosylation
BP TAS GO:0036498 IRE1-mediated unfolded protein response
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Gene expression in normal tissue: EXTL1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Breast cancer1

Pathways in EXTL1


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Database
Pathway ID
Pathway Des.
wikipathways WP3472 XBP1(S) activates chaperone genes
humancyc PWY-6558 heparan sulfate biosynthesis (late stages)
humancyc PWY-6564 heparan sulfate biosynthesis
kegg hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human)
reactome R-HSA-381038 XBP1(S) activates chaperone genes
reactome R-HSA-381070 IRE1alpha activates chaperones
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD133 Lapatinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EXTL1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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