EXTL1


Summary: This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
exostosin like glycosyltransferase 1MIM:601738Ensembl:ENSG00000158008HGNC:HGNC:3515PA279271p36.11

GO terms in EXTL1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0050508glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0016021integral component of membrane
BPTASGO:0001501skeletal system development
BPIEAGO:0006486protein glycosylation
BPTASGO:0036498IRE1-mediated unfolded protein response

Gene expression in normal tissue: EXTL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EXTL1


DatabasePathway IDPathway Des.
wikipathwaysWP3472XBP1(S) activates chaperone genes
humancycPWY-6558heparan sulfate biosynthesis (late stages)
humancycPWY-6564heparan sulfate biosynthesis
kegghsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human)
reactomeR-HSA-381038XBP1(S) activates chaperone genes
reactomeR-HSA-381070IRE1alpha activates chaperones
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD133Lapatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EXTL1

​​​​