ERP27


Summary: This gene encodes a noncatalytic member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. The canonical protein has an N-terminal signal sequence, two thioredoxin (TRX)-like domains and a C-terminal ER-retention sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which lack domains present in the canonical protein. [provided by RefSeq, Dec 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
endoplasmic reticulum protein 27MIM:610642Ensembl:ENSG00000139055HGNC:HGNC:26495PA16238540112p12.3

GO terms in ERP27


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003756protein disulfide isomerase activity
MFIPIGO:0005515protein binding
MFIBAGO:0031545peptidyl-proline 4-dioxygenase activity
CCIBAGO:0005783endoplasmic reticulum
CCIEAGO:0005788endoplasmic reticulum lumen
BPIBAGO:0006457protein folding
BPIBAGO:0034976response to endoplasmic reticulum stress
BPIBAGO:1902175regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Gene expression in normal tissue: ERP27

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ERP27


DatabasePathway IDPathway Des.
wikipathwaysWP3613Photodynamic therapy-induced unfolded protein response

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD133Lapatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ERP27

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