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ERP27

Summary: This gene encodes a noncatalytic member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. The canonical protein has an N-terminal signal sequence, two thioredoxin (TRX)-like domains and a C-terminal ER-retention sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which lack domains present in the canonical protein. [provided by RefSeq, Dec 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameendoplasmic reticulum protein 27 OMIM IDMIM:610642 Ensembl IDEnsembl:ENSG00000139055 HGNC IDHGNC:HGNC:26495 PHARMGKB IDPA162385401 Map Location12p12.3

GO terms in ERP27

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0003756	protein disulfide isomerase activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0031545	peptidyl-proline 4-dioxygenase activity
CC	IBA	GO:0005783	endoplasmic reticulum
CC	IEA	GO:0005788	endoplasmic reticulum lumen
BP	IBA	GO:0006457	protein folding

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Gene expression in normal tissue: ERP27

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ERP27

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Database	Pathway ID	Pathway Des.
wikipathways	WP3613	Photodynamic therapy-induced unfolded protein response

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD133	Lapatinib	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ERP27

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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