ERP27
Summary: This gene encodes a noncatalytic member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. The canonical protein has an N-terminal signal sequence, two thioredoxin (TRX)-like domains and a C-terminal ER-retention sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which lack domains present in the canonical protein. [provided by RefSeq, Dec 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| endoplasmic reticulum protein 27 | MIM:610642 | Ensembl:ENSG00000139055 | HGNC:HGNC:26495 | PA162385401 | 12p12.3 |
GO terms in ERP27
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003756 | protein disulfide isomerase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031545 | peptidyl-proline 4-dioxygenase activity |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005788 | endoplasmic reticulum lumen |
| BP | IBA | GO:0006457 | protein folding |
| BP | IBA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IBA | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
Gene expression in normal tissue: ERP27
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERP27
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERP27
CLASSFICATION
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