PIP4K2A
Summary: Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:603140 Ensembl IDEnsembl:ENSG00000150867 HGNC IDHGNC:HGNC:8997 PHARMGKB IDPA162399615 Map Location10p12.2 |
Gene Categories:
KINASEGO terms in PIP4K2A
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | TAS | GO:0005654 | nucleoplasm |
CC | IMP | GO:0005776 | autophagosome |
CC | TAS | GO:0005829 | cytosol |
CC | IEA | GO:0005886 | plasma membrane |
BP | TAS | GO:0006644 | phospholipid metabolic process |
BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
Gene expression in normal tissue: PIP4K2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIP4K2A
Database | Pathway ID | Pathway Des. |
---|---|---|
smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
smpdb | SMP00582 | Joubert syndrome |
wikipathways | WP51 | Regulation of Actin Cytoskeleton |
wikipathways | WP524 | G13 Signaling Pathway |
netpath | Pathway_BCR | BCR |
humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PIP4K2A
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |