PIP4K2A
Summary: Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol-5-phosphate 4-kinase type 2 alpha | MIM:603140 | Ensembl:ENSG00000150867 | HGNC:HGNC:8997 | PA162399615 | 10p12.2 |
Gene Categories:
KINASEGO terms in PIP4K2A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IMP | GO:0005776 | autophagosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| BP | TAS | GO:0006644 | phospholipid metabolic process |
| BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | IMP | GO:0010506 | regulation of autophagy |
| BP | TAS | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0035855 | megakaryocyte development |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IMP | GO:2000786 | positive regulation of autophagosome assembly |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | NAS | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| MF | EXP | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| MF | TAS | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| MF | TAS | GO:0052811 | 1-phosphatidylinositol-3-phosphate 4-kinase activity |
Gene expression in normal tissue: PIP4K2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIP4K2A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
| smpdb | SMP00582 | Joubert syndrome |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP524 | G13 Signaling Pathway |
| netpath | Pathway_BCR | BCR |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6367 | D-myo-inositol-5-phosphate metabolism |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804758 | Regulation of TP53 Activity through Acetylation |
| reactome | R-HSA-6811555 | PI5P Regulates TP53 Acetylation |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8847453 | Synthesis of PIPs in the nucleus |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD229 | B02 | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD297 | Austocystin D | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIP4K2A
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