PIP4K2A


Summary: Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008].

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OMIM ID
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Gene Categories:

KINASE

GO terms in PIP4K2A


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005654 nucleoplasm
CC IMP GO:0005776 autophagosome
CC TAS GO:0005829 cytosol
CC IEA GO:0005886 plasma membrane
BP TAS GO:0006644 phospholipid metabolic process
BP TAS GO:0006661 phosphatidylinositol biosynthetic process
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Gene expression in normal tissue: PIP4K2A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined19Cell cycle2Purine metabolism1PI3K/MTOR signaling1Apoptosis regulation1DNA replication1Leukocyte transendothelial migration1

Pathways in PIP4K2A


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Database
Pathway ID
Pathway Des.
smpdb SMP00463 Phosphatidylinositol Phosphate Metabolism
smpdb SMP00582 Joubert syndrome
wikipathways WP51 Regulation of Actin Cytoskeleton
wikipathways WP524 G13 Signaling Pathway
netpath Pathway_BCR BCR
humancyc PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD138 PX 12 3
iGMDRD158 NSC141540 3
iGMDRD231 Importazole 3
iGMDRD294 Batimastat 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIP4K2A

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Cancer
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