SDCCAG8


Summary: This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serologically defined colon cancer antigen 8MIM:613524Ensembl:ENSG00000054282HGNC:HGNC:10671PA356011q43-q44

Gene Categories:

TUMOR SUPPRESSOR

GO terms in SDCCAG8


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPIBAGO:0001764neuron migration
BPIEAGO:0001764neuron migration
BPIEAGO:0007098centrosome cycle
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPIBAGO:0030010establishment of cell polarity
BPISSGO:0030010establishment of cell polarity
BPIBAGO:0031023microtubule organizing center organization
BPIBAGO:0035148tube formation
BPISSGO:0035148tube formation
BPTASGO:0097711ciliary basal body-plasma membrane docking
CCIBAGO:0005813centrosome
CCIDAGO:0005813centrosome
CCIBAGO:0005814centriole
CCIDAGO:0005814centriole
CCTASGO:0005829cytosol
CCIDAGO:0005911cell-cell junction
CCIEAGO:0034451centriolar satellite

Gene expression in normal tissue: SDCCAG8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SDCCAG8


DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-380259Loss of Nlp from mitotic centrosomes
reactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexes
reactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosome
reactomeR-HSA-380287Centrosome maturation
reactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomes
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620912Anchoring of the basal body to the plasma membrane
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-8854518AURKA Activation by TPX2

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD885Compound 1102
iGMDRD158NSC1415402
iGMDRD255SB2250023
iGMDRD300Tozasertib1
iGMDRD23Gossypol4
iGMDRD268Cerulenin4
iGMDRD188Piperlongumine2
iGMDRD506Fedratinib2
iGMDRD562Navitoclax2
iGMDRD670ML 2102
iGMDRD307Manumycin A7
iGMDRD889Compound 7d-cis6
iGMDRD148Pifithrin-mu7
iGMDRD211(1S,3R)-RSL32
iGMDRD297Austocystin D3
iGMDRD280CYTOCHALASIN B1
iGMDRD634SCHEMBL26080415
iGMDRD446LY 21832403
iGMDRD201SKI II7
iGMDRD61Kinetin riboside2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SDCCAG8

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