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SDCCAG8

Summary: This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameserologically defined colon cancer antigen 8 OMIM IDMIM:613524 Ensembl IDEnsembl:ENSG00000054282 HGNC IDHGNC:HGNC:10671 PHARMGKB IDPA35601 Map Location1q43-q44

Gene Categories:

TUMOR SUPPRESSOR

GO terms in SDCCAG8

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
BP	TAS	GO:0000086	G2/M transition of mitotic cell cycle
BP	IBA	GO:0001764	neuron migration
BP	IEA	GO:0001764	neuron migration
BP	IEA	GO:0007098	centrosome cycle
BP	TAS	GO:0010389	regulation of G2/M transition of mitotic cell cycle

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Gene expression in normal tissue: SDCCAG8

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SDCCAG8

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-1852241	Organelle biogenesis and maintenance
reactome	R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition
reactome	R-HSA-380259	Loss of Nlp from mitotic centrosomes
reactome	R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes
reactome	R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD885	Compound 110	2
iGMDRD158	NSC141540	2
iGMDRD255	SB225002	3
iGMDRD300	Tozasertib	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SDCCAG8

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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