MAP3K20
Summary: This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 20 | MIM:609479 | Ensembl:ENSG00000091436 | HGNC:HGNC:17797 | 2q31.1 |
GO terms in MAP3K20
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| BP | IMP | GO:0000077 | DNA damage checkpoint |
| BP | TAS | GO:0000186 | activation of MAPKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007010 | cytoskeleton organization |
| BP | IMP | GO:0007050 | cell cycle arrest |
| BP | IDA | GO:0007093 | mitotic cell cycle checkpoint |
| BP | IDA | GO:0007257 | activation of JUN kinase activity |
| BP | NAS | GO:0008219 | cell death |
| BP | NAS | GO:0008283 | cell proliferation |
| BP | NAS | GO:0030154 | cell differentiation |
| BP | IMP | GO:0042733 | embryonic digit morphogenesis |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0051403 | stress-activated MAPK cascade |
| BP | IMP | GO:0060173 | limb development |
| BP | IDA | GO:0071480 | cellular response to gamma radiation |
| CC | IEA | GO:0005634 | nucleus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: MAP3K20
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K20
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p38gammadeltapathway | Signaling mediated by p38-gamma and p38-delta |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| wikipathways | WP382 | MAPK Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD679 | Bistramide A | 6 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD126 | Tipifarnib | 9 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD870 | BRD63610 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K20
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