CDX2
Summary: This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caudal type homeobox 2 | MIM:600297 | Ensembl:ENSG00000165556 | HGNC:HGNC:1806 | PA26352 | 13q12.2 |
GO terms in CDX2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0008327 | methyl-CpG binding |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001568 | blood vessel development |
| BP | IEA | GO:0001829 | trophectodermal cell differentiation |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008333 | endosome to lysosome transport |
| BP | IBA | GO:0009887 | animal organ morphogenesis |
| BP | TAS | GO:0009887 | animal organ morphogenesis |
| BP | IBA | GO:0009948 | anterior/posterior axis specification |
| BP | ISS | GO:0014807 | regulation of somitogenesis |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0035019 | somatic stem cell population maintenance |
| BP | IEA | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| BP | IEA | GO:0045597 | positive regulation of cell differentiation |
| BP | IEA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0060575 | intestinal epithelial cell differentiation |
| BP | IEA | GO:0060711 | labyrinthine layer development |
| CC | IEA | GO:0000794 | condensed nuclear chromosome |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0017053 | transcriptional repressor complex |
Gene expression in normal tissue: CDX2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDX2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400508 | Incretin synthesis, secretion, and inactivation |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3382 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation |
| wikipathways | WP3527 | Preimplantation Embryo |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD718 | Pyrvinium pamoate | 4 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD213 | SMR000068650 | 1 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD399 | Selumetinib | 9 |
| iGMDRD367 | Ro 28-1675 | 1 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD23 | Gossypol | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDX2
CLASSFICATION
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