TNKS2


Summary:

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tankyrase 2MIM:607128Ensembl:ENSG00000107854HGNC:HGNC:15677PA3801910q23.32

Gene Categories:

DRUGGABLE GENOME

GO terms in TNKS2


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000139Golgi membrane
CCIDAGO:0000242pericentriolar material
CCICGO:0000784nuclear chromosome, telomeric region
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005635nuclear envelope
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0048471perinuclear region of cytoplasm
BPIDAGO:0000209protein polyubiquitination
BPIBAGO:0006471protein ADP-ribosylation
BPIDAGO:0006471protein ADP-ribosylation
BPIEAGO:0016055Wnt signaling pathway
BPICGO:0032212positive regulation of telomere maintenance via telomerase
BPIEAGO:0035264multicellular organism growth
BPIEAGO:0040014regulation of multicellular organism growth
BPIBAGO:0070198protein localization to chromosome, telomeric region
BPIMPGO:0070198protein localization to chromosome, telomeric region
BPIDAGO:0070213protein auto-ADP-ribosylation
BPIBAGO:0090263positive regulation of canonical Wnt signaling pathway
BPIMPGO:0090263positive regulation of canonical Wnt signaling pathway
BPTASGO:0090263positive regulation of canonical Wnt signaling pathway
BPIBAGO:1904355positive regulation of telomere capping
BPIDAGO:1904355positive regulation of telomere capping
BPIMPGO:1904355positive regulation of telomere capping
BPIMPGO:1904357negative regulation of telomere maintenance via telomere lengthening
MFIBAGO:0003950NAD+ ADP-ribosyltransferase activity
MFIDAGO:0003950NAD+ ADP-ribosyltransferase activity
MFTASGO:0003950NAD+ ADP-ribosyltransferase activity
MFIPIGO:0005515protein binding
MFIPIGO:0019899enzyme binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: TNKS2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNKS2


DatabasePathway IDPathway Des.
wikipathwaysWP3645NAD+ biosynthetic pathways
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4641257Degradation of AXIN
reactomeR-HSA-4791275Signaling by WNT in cancer
reactomeR-HSA-5545619XAV939 inhibits tankyrase, stabilizing AXIN
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-8948751Regulation of PTEN stability and activity
reactomeR-HSA-9006925Intracellular signaling by second messengers

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 33
iGMDRD307Manumycin A3
iGMDRD405PIK-753
iGMDRD424Tamatinib3
iGMDRD945ML2143
iGMDRD121GMX17781
iGMDRD202Curcumin4
iGMDRD158NSC1415403
iGMDRD289Parthenolide3
iGMDRD105Triptolide2
iGMDRD434BMS-5369242
iGMDRD286Nsc 6328392
iGMDRD871BRD63684
iGMDRD367Ro 28-16753
iGMDRD414MST-3123
iGMDRD872BRD71373
iGMDRD246NPC264
iGMDRD552AZD-17752
iGMDRD599Salermide3
iGMDRD1008SR-II-138A3
iGMDRD126Tipifarnib2
iGMDRD433Lexibulin3
iGMDRD151CHM-13
iGMDRD144NSC953972
iGMDRD61Kinetin riboside3
iGMDRD8024-methylfasudil3
iGMDRD187BRD98763
iGMDRD171Pemetrexed3
iGMDRD188Piperlongumine5
iGMDRD100Zebularine3
iGMDRD887Compound 23 citrate3
iGMDRD399Selumetinib4
iGMDRD64Parbendazole2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNKS2

​​​​