TNKS2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tankyrase 2 | MIM:607128 | Ensembl:ENSG00000107854 | HGNC:HGNC:15677 | PA38019 | 10q23.32 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TNKS2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0000242 | pericentriolar material |
| CC | IC | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | IBA | GO:0006471 | protein ADP-ribosylation |
| BP | IDA | GO:0006471 | protein ADP-ribosylation |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IC | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0040014 | regulation of multicellular organism growth |
| BP | IBA | GO:0070198 | protein localization to chromosome, telomeric region |
| BP | IMP | GO:0070198 | protein localization to chromosome, telomeric region |
| BP | IDA | GO:0070213 | protein auto-ADP-ribosylation |
| BP | IBA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:1904355 | positive regulation of telomere capping |
| BP | IDA | GO:1904355 | positive regulation of telomere capping |
| BP | IMP | GO:1904355 | positive regulation of telomere capping |
| BP | IMP | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening |
| MF | IBA | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | IDA | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | TAS | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: TNKS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNKS2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3645 | NAD+ biosynthetic pathways |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4641257 | Degradation of AXIN |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-5545619 | XAV939 inhibits tankyrase, stabilizing AXIN |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-8948751 | Regulation of PTEN stability and activity |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD64 | Parbendazole | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNKS2
CLASSFICATION
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