NEDD9
Summary: The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602265 Ensembl IDEnsembl:ENSG00000111859 HGNC IDHGNC:HGNC:7733 PHARMGKB IDPA31538 Map Location6p24.2 | |||||
GO terms in NEDD9
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000922 | spindle pole |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005794 | Golgi apparatus |
Gene expression in normal tissue: NEDD9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEDD9
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEDD9
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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