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NLRP1

Summary: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NLR family pyrin domain containing 1	MIM:606636	Ensembl:ENSG00000091592	HGNC:HGNC:14374	PA162397797	17p13.2

Gene Categories:

PROTEASE

GO terms in NLRP1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005524	ATP binding
MF	NAS	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
MF	IPI	GO:0019899	enzyme binding
MF	IPI	GO:0019904	protein domain specific binding
CC	IC	GO:0005622	intracellular
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IBA	GO:0072558	NLRP1 inflammasome complex
CC	IDA	GO:0072558	NLRP1 inflammasome complex
CC	TAS	GO:0072558	NLRP1 inflammasome complex
BP	NAS	GO:0006915	apoptotic process
BP	IBA	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
BP	IDA	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
BP	NAS	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
BP	IEA	GO:0006954	inflammatory response
BP	IEA	GO:0016032	viral process
BP	ISS	GO:0032495	response to muramyl dipeptide
BP	ISS	GO:0042742	defense response to bacterium
BP	IEA	GO:0045087	innate immune response
BP	ISS	GO:0050718	positive regulation of interleukin-1 beta secretion
BP	IC	GO:0050727	regulation of inflammatory response
BP	IDA	GO:0051402	neuron apoptotic process
BP	IMP	GO:1904784	NLRP1 inflammasome complex assembly

Gene expression in normal tissue: NLRP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NLRP1

Database	Pathway ID	Pathway Des.
wikipathways	WP1433	Nucleotide-binding Oligomerization Domain (NOD) pathway
pid	anthraxpathway	Cellular roles of Anthrax toxin
kegg	hsa04621	NOD-like receptor signaling pathway - Homo sapiens (human)
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactome	R-HSA-622312	Inflammasomes
reactome	R-HSA-844455	The NLRP1 inflammasome

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD781	Sirolimus	2
iGMDRD484	Pluripotin	2
iGMDRD151	CHM-1	2
iGMDRD229	B02	3
iGMDRD1008	SR-II-138A	2
iGMDRD446	LY 2183240	3
iGMDRD71	Sparfosic acid	2
iGMDRD193	Fqi1	2
iGMDRD801	2,4-dideoxy-DC-45-A2	1
iGMDRD318	PAC-1	2
iGMDRD441	TW 37	1
iGMDRD885	Compound 110	3
iGMDRD138	PX 12	5
iGMDRD260	FQI-2	2
iGMDRD64	Parbendazole	1
iGMDRD188	Piperlongumine	2
iGMDRD100	Zebularine	2
iGMDRD399	Selumetinib	7
iGMDRD780	PP-30	3
iGMDRD560	MK-2206	1
iGMDRD307	Manumycin A	3
iGMDRD512	nutlin 3	4
iGMDRD211	(1S,3R)-RSL3	3
iGMDRD945	ML214	4
iGMDRD237	ABT-751	2
iGMDRD705	Nakiterpiosin	3
iGMDRD481	Dactolisib	3
iGMDRD231	Importazole	3
iGMDRD103	SN-38	3
iGMDRD137	Indisulam	2
iGMDRD202	Curcumin	4
iGMDRD414	MST-312	2
iGMDRD882	CIL41	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NLRP1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.