NLRP1

Summary: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameNLR family pyrin domain containing 1
OMIM IDMIM:606636
Ensembl IDEnsembl:ENSG00000091592
HGNC IDHGNC:HGNC:14374
PHARMGKB IDPA162397797
Map Location17p13.2

Gene Categories:

PROTEASE

GO terms in NLRP1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IDA GO:0005524 ATP binding
MF NAS GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
MF IPI GO:0019899 enzyme binding
MF IPI GO:0019904 protein domain specific binding
CC IC GO:0005622 intracellular
Showing 1 to 6 of 26 rows rows per page

Gene expression in normal tissue: NLRP1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 54BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 18BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 2OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 6

Gene-drug pathway distribution

undefined24PI3K/MTOR signaling2Apoptosis regulation2DNA replication1Stilbenoid, diarylheptanoid and gingerol biosynthesis1ERK MAPK signaling1Longevity regulating pathway1Ferroptosis1

Pathways in NLRP1


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP1433 Nucleotide-binding Oligomerization Domain (NOD) pathway
pid anthraxpathway Cellular roles of Anthrax toxin
kegg hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Showing 1 to 6 of 8 rows

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD781 Sirolimus 2
iGMDRD484 Pluripotin 2
iGMDRD151 CHM-1 2
iGMDRD229 B02 3
Showing 1 to 4 of 33 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NLRP1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.