TAF1L
Summary: This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interchangeably with the TAF1 product. [provided by RefSeq, Aug 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TATA-box binding protein associated factor 1 like | MIM:607798 | Ensembl:ENSG00000122728 | HGNC:HGNC:18056 | PA134947802 | 9p21.1 |
GO terms in TAF1L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly |
| MF | IBA | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly |
| MF | IBA | GO:0004402 | histone acetyltransferase activity |
| MF | ISS | GO:0004402 | histone acetyltransferase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0017025 | TBP-class protein binding |
| MF | IPI | GO:0017025 | TBP-class protein binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0070577 | lysine-acetylated histone binding |
| CC | ND | GO:0005575 | cellular_component |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005669 | transcription factor TFIID complex |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEP | GO:0007140 | male meiotic nuclear division |
| BP | IEA | GO:0016573 | histone acetylation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
Gene expression in normal tissue: TAF1L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAF1L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167161 | HIV Transcription Initiation |
| reactome | R-HSA-167162 | RNA Polymerase II HIV Promoter Escape |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73776 | RNA Polymerase II Promoter Escape |
| reactome | R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75953 | RNA Polymerase II Transcription Initiation |
| reactome | R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| kegg | hsa03022 | Basal transcription factors - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD255 | SB225002 | 7 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD446 | LY 2183240 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAF1L
CLASSFICATION
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