TBCK


Summary: This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TBC1 domain containing kinaseMIM:616899Ensembl:ENSG00000145348HGNC:HGNC:28261PA1656646034q24

GO terms in TBCK


Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0006468protein phosphorylation
BPIBAGO:0006886intracellular protein transport
BPIMPGO:0008283cell proliferation
BPIMPGO:0030036actin cytoskeleton organization
BPIMPGO:0032006regulation of TOR signaling
BPIBAGO:0090630activation of GTPase activity
CCIDAGO:0005737cytoplasm
CCIDAGO:0030496midbody
CCIDAGO:0072686mitotic spindle
MFNASGO:0004672protein kinase activity
MFIBAGO:0005096GTPase activator activity
MFNASGO:0005524ATP binding
MFIBAGO:0017137Rab GTPase binding

Gene expression in normal tissue: TBCK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TBCK


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD318PAC-17
iGMDRD138PX 124
iGMDRD270Ciclosporin2
iGMDRD260FQI-22
iGMDRD255SB2250022
iGMDRD60Quinoclamine4
iGMDRD64Parbendazole4
iGMDRD690PRIMA-1MET2
iGMDRD887Compound 23 citrate3
iGMDRD188Piperlongumine5
iGMDRD562Navitoclax3
iGMDRD506Fedratinib6
iGMDRD577BIX012947
iGMDRD144NSC9539710
iGMDRD781Sirolimus2
iGMDRD494Neopeltolide2
iGMDRD151CHM-11
iGMDRD126Tipifarnib3
iGMDRD280CYTOCHALASIN B6
iGMDRD446LY 21832404
iGMDRD193Fqi12
iGMDRD61Kinetin riboside2
iGMDRD434BMS-5369248
iGMDRD289Parthenolide4
iGMDRD105Triptolide4
iGMDRD705Nakiterpiosin4
iGMDRD251ML1624
iGMDRD158NSC1415402
iGMDRD271Brefeldin A2
iGMDRD552AZD-17753
iGMDRD246NPC264
iGMDRD147Prima-12
iGMDRD300Tozasertib2
iGMDRD505Pevonedistat9
iGMDRD886Compound 1541A4
iGMDRD872BRD71373
iGMDRD286Nsc 6328394
iGMDRD871BRD63685
iGMDRD366PI-1032
iGMDRD532Olaparib2
iGMDRD79Gemcitabine2
iGMDRD486Tosedostat2
iGMDRD307Manumycin A2
iGMDRD123Isoevodiamine2
iGMDRD435BI-25363
iGMDRD945ML2144
iGMDRD883CIL55A3
iGMDRD57Chloropentafluorobenzene3
iGMDRD351GW843682X1
iGMDRD314Tanespimycin2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TBCK

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