TBCK
Summary: This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TBC1 domain containing kinase | MIM:616899 | Ensembl:ENSG00000145348 | HGNC:HGNC:28261 | PA165664603 | 4q24 |
GO terms in TBCK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IMP | GO:0030036 | actin cytoskeleton organization |
| BP | IMP | GO:0032006 | regulation of TOR signaling |
| BP | IBA | GO:0090630 | activation of GTPase activity |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0072686 | mitotic spindle |
| MF | NAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0005096 | GTPase activator activity |
| MF | NAS | GO:0005524 | ATP binding |
| MF | IBA | GO:0017137 | Rab GTPase binding |
Gene expression in normal tissue: TBCK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TBCK
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 7 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD144 | NSC95397 | 10 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD434 | BMS-536924 | 8 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD251 | ML162 | 4 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD505 | Pevonedistat | 9 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD314 | Tanespimycin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TBCK
CLASSFICATION
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