TBCK
Summary: This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:616899 Ensembl IDEnsembl:ENSG00000145348 HGNC IDHGNC:HGNC:28261 PHARMGKB IDPA165664603 Map Location4q24 | |||||
GO terms in TBCK
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IMP | GO:0030036 | actin cytoskeleton organization |
| BP | IMP | GO:0032006 | regulation of TOR signaling |
| BP | IBA | GO:0090630 | activation of GTPase activity |
Gene expression in normal tissue: TBCK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TBCK
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TBCK
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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