DLL4


Summary: This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
delta like canonical Notch ligand 4MIM:605185Ensembl:ENSG00000128917HGNC:HGNC:2910PA2736615q15.1

Gene Categories:

DRUGGABLE GENOME

GO terms in DLL4


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0001525angiogenesis
BPISSGO:0001569branching involved in blood vessel morphogenesis
BPISSGO:0001974blood vessel remodeling
BPISSGO:0003208cardiac ventricle morphogenesis
BPISSGO:0003209cardiac atrium morphogenesis
BPISSGO:0003222ventricular trabecula myocardium morphogenesis
BPISSGO:0003344pericardium morphogenesis
BPTASGO:0007165signal transduction
BPTASGO:0007219Notch signaling pathway
BPIEAGO:0007601visual perception
BPTASGO:0008015blood circulation
BPIMPGO:0008285negative regulation of cell proliferation
BPIMPGO:0010596negative regulation of endothelial cell migration
BPIDAGO:0010628positive regulation of gene expression
BPIDAGO:0010629negative regulation of gene expression
BPISSGO:0030217T cell differentiation
BPISSGO:0035912dorsal aorta morphogenesis
BPIMPGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIDAGO:0044344cellular response to fibroblast growth factor stimulus
BPISSGO:0045746negative regulation of Notch signaling pathway
BPISSGO:0045747positive regulation of Notch signaling pathway
BPIEAGO:0050767regulation of neurogenesis
BPIMPGO:0060579ventral spinal cord interneuron fate commitment
BPISSGO:0061074regulation of neural retina development
BPISSGO:0061314Notch signaling involved in heart development
BPIEAGO:0072554blood vessel lumenization
BPIDAGO:0090051negative regulation of cell migration involved in sprouting angiogenesis
BPIMPGO:0090051negative regulation of cell migration involved in sprouting angiogenesis
BPIDAGO:1903588negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
BPISSGO:2000179positive regulation of neural precursor cell proliferation
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
MFIEAGO:0005112Notch binding
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: DLL4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DLL4


DatabasePathway IDPathway Des.
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-2122948Activated NOTCH1 Transmits Signal to the Nucleus
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2660825Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
reactomeR-HSA-2660826Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
reactomeR-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in Cancer
reactomeR-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain Mutants
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-2979096NOTCH2 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-2979096NOTCH2 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9013700NOTCH4 Activation and Transmission of Signal to the Nucleus
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP3413NOTCH1 regulation of human endothelial cell calcification
wikipathwaysWP3845Canonical and Non-canonical Notch signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP61Notch Signaling Pathway
kegghsa04330Notch signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
pidnotch_pathwayNotch signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD532Olaparib2
iGMDRD79Gemcitabine2
iGMDRD781Sirolimus2
iGMDRD307Manumycin A3
iGMDRD554CHEMBL14341372
iGMDRD584VER 1550082
iGMDRD889Compound 7d-cis3
iGMDRD280CYTOCHALASIN B4
iGMDRD123Isoevodiamine3
iGMDRD945ML2142
iGMDRD57Chloropentafluorobenzene4
iGMDRD434BMS-5369245
iGMDRD105Triptolide1
iGMDRD8012,4-dideoxy-DC-45-A25
iGMDRD318PAC-11
iGMDRD138PX 126
iGMDRD158NSC1415405
iGMDRD103SN-382
iGMDRD246NPC262
iGMDRD147Prima-12
iGMDRD300Tozasertib2
iGMDRD505Pevonedistat2
iGMDRD690PRIMA-1MET6
iGMDRD286Nsc 6328391
iGMDRD367Ro 28-16752

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DLL4

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