DLL4
Summary: This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| delta like canonical Notch ligand 4 | MIM:605185 | Ensembl:ENSG00000128917 | HGNC:HGNC:2910 | PA27366 | 15q15.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in DLL4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001569 | branching involved in blood vessel morphogenesis |
| BP | ISS | GO:0001974 | blood vessel remodeling |
| BP | ISS | GO:0003208 | cardiac ventricle morphogenesis |
| BP | ISS | GO:0003209 | cardiac atrium morphogenesis |
| BP | ISS | GO:0003222 | ventricular trabecula myocardium morphogenesis |
| BP | ISS | GO:0003344 | pericardium morphogenesis |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | IEA | GO:0007601 | visual perception |
| BP | TAS | GO:0008015 | blood circulation |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0010596 | negative regulation of endothelial cell migration |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010629 | negative regulation of gene expression |
| BP | ISS | GO:0030217 | T cell differentiation |
| BP | ISS | GO:0035912 | dorsal aorta morphogenesis |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IDA | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| BP | ISS | GO:0045746 | negative regulation of Notch signaling pathway |
| BP | ISS | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | IEA | GO:0050767 | regulation of neurogenesis |
| BP | IMP | GO:0060579 | ventral spinal cord interneuron fate commitment |
| BP | ISS | GO:0061074 | regulation of neural retina development |
| BP | ISS | GO:0061314 | Notch signaling involved in heart development |
| BP | IEA | GO:0072554 | blood vessel lumenization |
| BP | IDA | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| BP | IMP | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| BP | IDA | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| BP | ISS | GO:2000179 | positive regulation of neural precursor cell proliferation |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | IEA | GO:0005112 | Notch binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: DLL4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DLL4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer |
| reactome | R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP3413 | NOTCH1 regulation of human endothelial cell calcification |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| pid | notch_pathway | Notch signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD532 | Olaparib | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 4 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 5 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD690 | PRIMA-1MET | 6 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD367 | Ro 28-1675 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DLL4
CLASSFICATION
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