DLL4

Summary: This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namedelta like canonical Notch ligand 4
OMIM IDMIM:605185
Ensembl IDEnsembl:ENSG00000128917
HGNC IDHGNC:HGNC:2910
PHARMGKB IDPA27366
Map Location15q15.1

Gene Categories:

DRUGGABLE GENOME

GO terms in DLL4


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Term Type
Evidence Type
GO Term ID
GO Des.
BP ISS GO:0000122 negative regulation of transcription by RNA polymerase II
BP ISS GO:0001525 angiogenesis
BP ISS GO:0001569 branching involved in blood vessel morphogenesis
BP ISS GO:0001974 blood vessel remodeling
BP ISS GO:0003208 cardiac ventricle morphogenesis
BP ISS GO:0003209 cardiac atrium morphogenesis
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Gene expression in normal tissue: DLL4

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 39BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 9LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 23

Gene-drug pathway distribution

Pathways in DLL4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1643685 Disease
reactome R-HSA-1980143 Signaling by NOTCH1
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD532 Olaparib 2
iGMDRD79 Gemcitabine 2
iGMDRD781 Sirolimus 2
iGMDRD307 Manumycin A 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DLL4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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