MAPK11

Summary: This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemitogen-activated protein kinase 11
OMIM IDMIM:602898
Ensembl IDEnsembl:ENSG00000185386
HGNC IDHGNC:HGNC:6873
PHARMGKB IDPA30618
Map Location22q13.33

GO terms in MAPK11


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004707 MAP kinase activity
MF IDA GO:0004707 MAP kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
CC IBA GO:0005634 nucleus
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Gene expression in normal tissue: MAPK11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined19Cell cycle1PI3K/MTOR signaling1Longevity regulating pathway1Mitosis1

Pathways in MAPK11


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Database
Pathway ID
Pathway Des.
pid atf2_pathway ATF-2 transcription factor network
pid cd40_pathway CD40/CD40L signaling
pid cxcr3pathway CXCR3-mediated signaling events
pid er_nongenomic_pathway Plasma membrane estrogen receptor signaling
pid faspathway FAS (CD95) signaling pathway
pid il2_1pathway IL2-mediated signaling events
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD226 ML006 2
iGMDRD105 Triptolide 2
iGMDRD255 SB225002 6
iGMDRD121 GMX1778 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPK11

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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