CDK14
Summary: PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 14 | MIM:610679 | Ensembl:ENSG00000058091 | HGNC:HGNC:8883 | PA33221 | 7q21.13 |
GO terms in CDK14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IMP | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0030332 | cyclin binding |
| MF | IPI | GO:0030332 | cyclin binding |
| BP | IDA | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IDA | GO:0060828 | regulation of canonical Wnt signaling pathway |
| CC | IDA | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
Gene expression in normal tissue: CDK14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK14
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD781 | Sirolimus | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK14
CLASSFICATION
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