STK26


Summary: The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serine/threonine kinase 26MIM:300547Ensembl:ENSG00000134602HGNC:HGNC:18174PA166123740Xq26.2

GO terms in STK26


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000165MAPK cascade
BPIEAGO:0000165MAPK cascade
BPIEAGO:0000185activation of MAPKKK activity
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0006468protein phosphorylation
BPIEAGO:0006915apoptotic process
BPIBAGO:0007346regulation of mitotic cell cycle
BPIMPGO:0009267cellular response to starvation
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIDAGO:0030033microvillus assembly
BPIMPGO:0030336negative regulation of cell migration
BPIBAGO:0032147activation of protein kinase activity
BPIDAGO:0042542response to hydrogen peroxide
BPIDAGO:0042981regulation of apoptotic process
BPIMPGO:0046777protein autophosphorylation
BPIBAGO:0048812neuron projection morphogenesis
BPIMPGO:1903205regulation of hydrogen peroxide-induced cell death
CCIEAGO:0000139Golgi membrane
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005798Golgi-associated vesicle
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0012506vesicle membrane
CCIDAGO:0016020membrane
CCIDAGO:0016324apical plasma membrane
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCIDAGO:0071944cell periphery
MFIDAGO:0000287magnesium ion binding
MFIDAGO:0004672protein kinase activity
MFIMPGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0042803protein homodimerization activity

Gene expression in normal tissue: STK26

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STK26


DatabasePathway IDPathway Des.
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-111465Apoptotic cleavage of cellular proteins
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-75153Apoptotic execution phase
pidlkb1_pathwayLKB1 signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD889Compound 7d-cis6
iGMDRD307Manumycin A6
iGMDRD138PX 123
iGMDRD158NSC1415406
iGMDRD79Gemcitabine3
iGMDRD8012,4-dideoxy-DC-45-A26
iGMDRD532Olaparib3
iGMDRD201SKI II1
iGMDRD872BRD71373
iGMDRD871BRD63686
iGMDRD147Prima-13
iGMDRD690PRIMA-1MET6
iGMDRD901ELCPK3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STK26

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