TAL1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TAL bHLH transcription factor 1, erythroid differentiation factor | MIM:187040 | Ensembl:ENSG00000162367 | HGNC:HGNC:11556 | PA36326 | 1p33 |
GO terms in TAL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0033193 | Lsd1/2 complex |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007626 | locomotory behavior |
| BP | IEA | GO:0021527 | spinal cord association neuron differentiation |
| BP | ISS | GO:0030097 | hemopoiesis |
| BP | IEP | GO:0030218 | erythrocyte differentiation |
| BP | IMP | GO:0030218 | erythrocyte differentiation |
| BP | IEP | GO:0030219 | megakaryocyte differentiation |
| BP | IEA | GO:0030220 | platelet formation |
| BP | IEP | GO:0030221 | basophil differentiation |
| BP | IDA | GO:0031334 | positive regulation of protein complex assembly |
| BP | ISS | GO:0035162 | embryonic hemopoiesis |
| BP | IEA | GO:0035855 | megakaryocyte development |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IEA | GO:0043249 | erythrocyte maturation |
| BP | ISS | GO:0045165 | cell fate commitment |
| BP | IDA | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | ISS | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | IMP | GO:0045799 | positive regulation of chromatin assembly or disassembly |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0051781 | positive regulation of cell division |
| BP | IEA | GO:0060018 | astrocyte fate commitment |
| BP | IEA | GO:0060216 | definitive hemopoiesis |
| BP | IEA | GO:0060217 | hemangioblast cell differentiation |
| BP | IEA | GO:0060218 | hematopoietic stem cell differentiation |
| BP | IEA | GO:0060375 | regulation of mast cell differentiation |
| BP | TAS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| BP | IEA | GO:2000036 | regulation of stem cell population maintenance |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IPI | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | ISS | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IDA | GO:0070888 | E-box binding |
Gene expression in normal tissue: TAL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| wikipathways | WP3987 | HDAC6 interactions |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD307 | Manumycin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAL1
CLASSFICATION
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