IRAK2

Summary: IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinterleukin 1 receptor associated kinase 2
OMIM IDMIM:603304
Ensembl IDEnsembl:ENSG00000134070
HGNC IDHGNC:HGNC:6113
PHARMGKB IDPA29913
Map Location3p25.3

GO terms in IRAK2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IPI GO:0042803 protein homodimerization activity
MF IPI GO:0046982 protein heterodimerization activity
BP TAS GO:0000187 activation of MAPK activity
Showing 1 to 6 of 33 rows rows per page

Gene expression in normal tissue: IRAK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined24Mitosis1Other, kinases1DNA replication1Protein stability and degradation1IGFR signaling1Chromatin histone methylation1Purine metabolism1

Pathways in IRAK2


Loading, please wait...
Database
Pathway ID
Pathway Des.
biocarta il1rpathway signal transduction through il1r
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
reactome R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
reactome R-HSA-166166 MyD88-independent TLR4 cascade
reactome R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
Showing 1 to 6 of 42 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD652 UNC0638 2
iGMDRD79 Gemcitabine 6
iGMDRD546 BMS-754807 1
iGMDRD889 Compound 7d-cis 2
Showing 1 to 4 of 31 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRAK2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.