TRIM36
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tripartite motif containing 36 | MIM:609317 | Ensembl:ENSG00000152503 | HGNC:HGNC:16280 | PA38111 | 5q22.3 |
GO terms in TRIM36
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004842 | ubiquitin-protein transferase activity |
| MF | ISS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | ISS | GO:0043014 | alpha-tubulin binding |
| BP | TAS | GO:0000209 | protein polyubiquitination |
| BP | IMP | GO:0000281 | mitotic cytokinesis |
| BP | IMP | GO:0007051 | spindle organization |
| BP | IEA | GO:0007340 | acrosome reaction |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IMP | GO:0070507 | regulation of microtubule cytoskeleton organization |
| CC | IEA | GO:0001669 | acrosomal vesicle |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
Gene expression in normal tissue: TRIM36
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIM36
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD137 | Indisulam | 8 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD64 | Parbendazole | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIM36
CLASSFICATION
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